Startups don't die when they run out of cash, they die when the founders run out of energy.

Next time a VC asks "What if Google does this?" counter "What if Google enters the VC business?" / via @harjeet

Three things in life - your health, your mission, and the people you love. That's it.

It's never been easier to start a company. It's never been harder to build one.

Mathematicians look down on Physicists, who look down on Engineers, who look down on Designers. And Designers look down on everyone.

Pitching skills are overrated. Find the right co-founder. Attack the right market. Craft the right product. Investors will pitch you.

You have to pick something big to work on, because it's hard to commit your life to something small.

Highly recommend that every would-be investor start a company first. It's hard to understand pain in the abstract.

I never met my greatest mentor. I wanted so much to be like him. But, his message was the opposite. Be yourself, with passionate intensity.

My 1 repeated learning in life: "There Are No Adults" Everyone's making it up as they go along. Figure it out yourself, and do it.

Imagine an online school where top scientists lecture a million kids at zero marginal cost. Add rigorous testing, diplomas. Goodbye college.

Note to world - 95% of what you want to meet for can be easily handled in a 5-minute email exchange. Be efficient! http://t.co/UXW2zr61

The secret currency of Silicon Valley is deals shared, talent referred, and acquirers introduced.

We didn't set out to build a product. We set out to solve a problem.

To make an original contribution, you have to be irrationally obsessed with something.

Before you search for product / market fit, make sure your passion / product fit. It's a long journey.

All those processes you put in place to make sure that "it doesn't happen again" - are destroying your organization's ability to innovate.

In a negotiation, whoever cares less, wins.

Society is not yet ready to deal with the productivity (and income) disparity between a leveraged hacker and a 20th century worker.

If you can't decide, the answer is No.